• A POWERFUL RESEARCH AND
    DEVELOPMENT ENGINE

    Our unique ability to repeatedly and consistently translate science into medicine has led to a robust pipeline of clinical-stage medicines, all of which were discovered in our laboratories. Our investigational treatments target allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neuromuscular diseases, infectious diseases and rare diseases.

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    Regeneron Pipeline: Phase 1 Medicines Regeneron Pipeline: Phase 1 Medicines
    • CEMIPLIMAB*
      PD-1 Antibody Cancer
    • REGN3767
      LAG-3 Antibody Solid tumors, advanced hematologic malignancies
    • REGN1979
      CD20 X CD3 Antibody B-cell malignancies
    • REGN4018*
      MUC16 X CD3 Antibody Platinum-resistant ovarian cancer
    • REGN5458*
      BCMA X CD3 Antibody Multiple myeloma
    • REGN5459*
      BCMA X CD3 Antibody Multiple myeloma
    • REGN5678
      PSMA X CD28 Antibody Prostate cancer
    • REGN5093
      MET X MET Antibody MET-altered advanced non-small cell lung cancer (NSCLC)
    • REGN5713-5714-5715
      Bet v 1 Antibodies Birch Allergy
    Regeneron Pipeline: Phase 2 Medicines Regeneron Pipeline: Phase 2 Medicines
    • AFLIBERCEPT
      VEGF-Trap High-dose (8mg) for wet age-related macular degeneration (AMD)
    • CEMIPLIMAB*
      PD-1 Antibody Basal cell carcinoma (BCC), metastatic or locally advanced cutaneous squamous cell carcinoma (CSCC), neoadjuvant CSCC
    • REGN1979
      CD20 X CD3 Antibody B-cell non-Hodgkin lymphoma
    • SARILUMAB*
      IL-6R Antibody Polyarticular-course juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis
    • DUPILUMAB*
      IL-4R Antibody Grass allergy, peanut allergy
    • REGN1908-1909
      Fel d 1 Antibodies Cat allergy
    • REGN3500*
      IL-33 Antibody Asthma, chronic obstructive pulmonary disease (COPD)
    • REGN5069
      GFRα3 Antibody Osteoarthritis pain of the knee
    • GARETOSMAB
      Activin A Antibody Fibrodysplasia Ossificans Progressiva (FOP)
    • EVINACUMAB
      ANGPTL-3 Antibody Refractory hypercholesterolemia (both HeFH and non-FH), severe hypertriglyceridemia
    • POZELIMAB
      C5 Antibody Paroxysmal nocturnal hemoglobinuria, CD-55 deficient protein-losing enteropathy
    • REGN4461
      LEPR Antibody Generalized lipodystrophy
    Regeneron Pipeline: Phase 3 Medicines Regeneron Pipeline: Phase 3 Medicines
    • AFLIBERCEPT
      VEGF-Trap Retinopathy of prematurity (ROP)
    • CEMIPLIMAB*
      PD-1 Antibody non-small cell lung cancer (NSCLC), cervical cancer, adjuvant cutaneous squamous cell carcinoma (CSCC)
    • ALIROCUMAB
      PCSK9 Antibody Homozygous familial hypercholesterolemia (HoFH) in adults and pediatric patients, heterozygous familial hypercholesterolemia in pediatric patients
    • EVINACUMAB
      ANGPTL-3 Antibody Homozygous familial hypercholesterolemia (HoFH)
    • DUPILUMAB*
      IL-4R Antibody Atopic dermatitis in pediatric patients 6 mo.–11 y.o., asthma in pediatric patients 6-11 y.o., eosinophilic esophagitis, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, prurigo nodularis, chronic spontaneous urticaria
    • SARILUMAB*
      IL-6R Antibody Hospitalized "critical" COVID-19 patients, polymyalgia rheumatica, giant cell arteritis
    • REGN-EB3
      Ebola Virus Antibodies Ebola virus infection
    • FASINUMAB?
      NGF Antibody Osteoarthritis pain of the knee or hip

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    * In collaboration with Sanofi

    ? In collaboration with Teva and Mitsubishi Tanabe

    This graphic displays pipeline drug candidates currently undergoing clinical testing in a variety of diseases. The safety and efficacy of these drug candidates have not been fully evaluated by any regulatory authorities for the indications described in this section.

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